Correlation of Extract Composition on Antioxidant Activity of ELECTROSPUN PolyvinylPyrrolidone/Bassela rubra linn Leaf Extract Composite

Eka Lutfi Septiani^1,a*, Azmi Alvian Gabriel¹, Okky Putri Prastuti¹, Defi Nur Indahsari¹, Ervina Diah Ariyanti¹, Siti Machmudah^2,b*, Sugeng Winardi², Wahyudiono³, Hideki Kanda³ and Motonobu Goto³

¹Department of Chemical Engineering, Universitas Internasional Semen Indonesia, Kompleks PT. Semen Indonesia (Persero) Tbk, Jl. Veteran, Gresik 61122, Indonesia

²Department of Chemical Engineering, Institut Teknologi Sepuluh Nopember, Kampus ITS Sukolilo, Surabaya 60111, Indonesia

³Department of Material Process Engineering, Nagoya University, Furo-Cho, Chikusa-Ku, Nagoya 464-8603, Japan

^aeka.septiani@uisi.ac.id, ^bsitimach@gmail.com

Abstract

Nanofiber through electrospinning process has been developed as a promising material for wound dressing due to its large porosity and high surface area. This characteristic of nanofiber provides an adequate gas permeability surrounding the wound which prevents the healing failure. The best wound dressing not only maintain a wound to have a good gas permeability but also to have an active agent giving an antibacterial and antiinflammation property. This research aims to combine a synthetic polymer and active agent, polyvinylpyrrolidone (PVP) and Bassela rubra linn leaf extract (BRLE), become nanofibrous material. The electrospinning process was conducted in two steps. The first step is to obtain the best voltage of PVP electrospinning by using the voltage of 10, 12, 15, 17 kV. The other step is combining PVP to 2%, 5%, 8% of BRLE. The first step shows the best operation condition is using 12 kV. Hence, it is used to obtain nanofiber with different BRLE percentage. Based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the result indicates that increase the BRLE composition will rise the antioxidant activity because of the smaller diameter size.

Keywords: nanofiber, electrospinning, Basella rubra linn (binahong) extract, antioxidant activity

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